Allulose & GLP-1: Can a Sweetener Work to Help You Lose Weight?
Natural GLP-1 Power
You’ve heard of Ozempic and Wegovy. Now meet Allulose—a naturally occurring sweetener that may trigger similar effects in the body, without the prescription.
GLP-1 medications like Ozempic and Wegovy have taken center stage for their ability to reduce appetite, support blood sugar stability, and promote sustainable weight loss. But recent research shows that allulose, the low-calorie, low-carb sweetener we use in every Two Spoons pint, may also stimulate the body’s natural GLP-1 release.
So… What Is GLP-1?
GLP-1 (Glucagon-Like Peptide-1) is a hormone released from the gut after eating. It helps manage blood sugar, promotes feelings of fullness, slows digestion, and supports energy balance. It’s one of the reasons GLP-1 medications have become so popular—they mimic this hormone's effects, helping people manage weight and improve metabolic health.
Why We Use Allulose in Every Pint
We already loved allulose for its taste and health profile—it has 90% fewer calories than sugar, doesn’t spike blood sugar, and doesn’t mess with your gut. But now there’s more: studies suggest allulose may naturally stimulate GLP-1 release, giving it potential appetite-regulating and blood sugar benefits.
Each serving of Two Spoons ice cream contains at least 6g of allulose—one of the highest amounts in any frozen dessert. That means you're not just satisfying your sweet tooth. You're potentially supporting metabolic health with every bite.
Why It Matters for Weight Management
GLP-1 plays a huge role in:
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Glucose management for people with or at risk of Type 2 Diabetes
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Appetite control and satiety
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Weight loss support
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Reduced risk of heart disease
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Overall metabolic balance
We’re not saying ice cream is a drug. But if there’s a way to indulge and still support your body’s natural systems—why wouldn’t we?
🍨 Spoonful of Answers
Q: What is allulose, and how is it different from other sweeteners?
A: Allulose is a rare sugar found in fruits like figs. It has 90% fewer calories than sugar, doesn’t raise blood sugar, and may support GLP-1 release in the body.
Q: Can allulose really support weight loss?
A: Emerging research shows that allulose may trigger the release of GLP-1, the same hormone activated by weight-loss drugs like Ozempic. While more studies are needed, early results are promising.
Q: Why does Two Spoons use allulose instead of stevia or erythritol?
A: Allulose delivers the sweetness and mouthfeel of sugar, without the aftertaste or digestive issues of other alt sweeteners. Plus, it supports blood sugar regulation and may promote satiety.
📚 References & Further Reading
GLP-1 Studies:
- Tani, Y., Tokuda, M., Nishimoto, N., Yokoi, H., & Izumori, K. (2023, April 6). Allulose for the attenuation of postprandial blood glucose levels in healthy humans: A systematic review and meta-analysis. PLoS One. https://doi.org/10.1371/journal.pone.0281150
- Fukunaga, K., Yoshimura, T., Imachi, H., Kobayashi, T., Saheki, T., Sato, S., Saheki, N., Jiang, W., & Murao, K. (2023). A Pilot Study on the Efficacy of a Diabetic Diet Containing the Rare Sugar D-Allulose in Patients with Type 2 Diabetes Mellitus: A Prospective, Randomized, Single-Blind, Crossover Study. Nutrients, 15(12), 2802. https://doi.org/10.3390/nu15122802
- Iwasaki, Y., Sendo, M., Dezaki, K., Hira, T., Sato, T., Nakata, M., Goswami, C., Aoki, R., Arai, T., Kumari, P., Hayakawa, M., Masuda, C., Okada, T., Hara, H., Drucker, D. J., Yamada, Y., Tokuda, M., & Yada, T. (2018). GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose. Nature Communications, 9, 113. https://doi.org/10.1038/s41467-017-02592-8
- Rakhat, Y., Kaneko, K., Wang, L., Han, W., Seino, Y., Yabe, D., & Yada, T. (2022). d-Allulose Inhibits Ghrelin-Responsive, Glucose-Sensitive and Neuropeptide Y Neurons in the Arcuate Nucleus and Central Injection Suppresses Appetite-Associated Food Intake in Mice. Nutrients, 14(15), 3117. https://doi.org/10.3390/nu14153117
- Yermek, R., Wang, L., Kaneko, K., Han, W., Seino, Y., Yabe, D., & Yada, T. (2022). D-Allulose cooperates with glucagon-like peptide-1 and activates proopiomelanocortin neurons in the arcuate nucleus and central injection inhibits feeding in mice. Biochemical and Biophysical Research Communications, 613, 159-165. https://doi.org/10.1016/j.bbrc.2022.05.083
- Han, Y., Kwon, E.-Y., Yu, M. K., Lee, S. J., Kim, H.-J., Kim, S.-B., Kim, Y. H., & Choi, M.-S. (2018). A Preliminary Study for Evaluating the Dose-Dependent Effect of d-Allulose for Fat Mass Reduction in Adult Humans: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients, 10(2), 160. https://doi.org/10.3390/nu10020160
Other:
- Hossain, A., Yamaguchi, F., Matsuo, T., Tsukamoto, I., Toyoda, Y., Ogawa, M., Nagata, Y., & Tokuda, M. (2015). Rare sugar d-allulose: Potential role and therapeutic monitoring in maintaining obesity and type 2 diabetes mellitus. Pharmacology & Therapeutics, 155, 49-59. https://doi.org/10.1016/j.pharmthera.2015.08.004
- Ochiai, M., Onishi, K., Yamada, T., Iida, T., & Matsuo, T. (2014). d-Psicose increases energy expenditure and decreases body fat accumulation in rats fed a high-sucrose diet. International Journal of Food Sciences and Nutrition, 65(2), 245-250. https://doi.org/10.3109/09637486.2013.845653
- Perlmutter, D. (July 19, 2023). Yes, I'm excited about allulose. Dr. Perlmutter. https://drperlmutter.com/yes-im-excited-allulose/
